Resource Type

Journal Article 6

Year

2023 1

2017 2

2015 1

2013 1

Keywords

cell penetrating peptides 2

Antibiotic alternatives 1

Antifreeze peptides 1

Bone tissue engineering 1

Chemotactic/haptotactic factors 1

Cryopreservation 1

Evolution analysis 1

Ice recrystallization inhibition 1

Mesenchymal stem cells 1

Mg-doped hydroxyapatite 1

Microbial-derived AMPs 1

Molecular dynamics simulation 1

Sustainable agricultural systems 1

Synthetic biology 1

amphipathic peptides 1

bio-macromolecular drugs 1

delivery systems 1

drug delivery 1

enzyme-instructed self-assembly 1

phosphatase 1

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Cationic and amphipathic cell-penetrating peptides (CPPs): Their structures and

Jennica L. Zaro,Wei-Chiang Shen

Frontiers of Chemical Science and Engineering 2015, Volume 9, Issue 4,   Pages 407-427 doi: 10.1007/s11705-015-1538-y

Abstract: Over the past few decades, cell penetrating peptides (CPPs) have become an important class of drug carriers30 amino acids), generally classified as cationic or amphipathic, with various mechanisms in cellular

Keywords： cell penetrating peptides     amphipathic peptides     drug delivery    

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Enzyme-instructed self-assembly of peptides containing phosphoserine to form supramolecular hydrogels

Jie Zhou, Xuewen Du, Jiaqing Wang, Natsuko Yamagata, Bing Xu

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 509-515 doi: 10.1007/s11705-017-1613-7

Abstract: phosphatase, but the study of the substrates of phosphatases mainly focuses on the phosphotyrosine containing peptidesIn this work, we examine the EISA of phosphoserine containing small peptides for the first time by designingprovides insights on how the specific molecular structures influence self-assembling behaviors of small peptidesMoreover, the utilization of D-amino acids largely enhances the biostability of the peptides, thus providing

Keywords： enzyme-instructed self-assembly     phosphoserine     phosphatase     supramolecular hydrogel    

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Significance and strategies in developing delivery systems for bio-macromolecular drugs

Huining HE, Qiuling LIANG, Meong Cheol SHIN, Kyuri LEE, Junbo GONG, Junxiao YE, Quan LIU, Jingkang WANG, Victor YANG

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 4,   Pages 496-507 doi: 10.1007/s11705-013-1362-1

Abstract: Successful development of a new drug is prohibitively expensive, and is estimated to cost approximately $100–500 million US dollars for a single clinical drug. Yet, a newly developed drug can only enjoy its patent protection for 18 years, meaning that after this protected time period, any company can manufacture this product and thus the profit generated by this drug entity would reduce dramatically. Most critically, once a drug is being synthesized, its physical, chemical, and biological attributes such as bioavailability and in vivo pharmacokinetics are all completely fixed and cannot be changed. In principal and practice, only the application of an appropriately designed drug delivery system (DDS) is able to overcome such limitations, and yet the cost of developing a novel drug delivery system is less than 10% of that of developing a new drug. Because of these reasons, the new trend in pharmaceutical development has already begun to shift from the single direction of developing new drugs in the past to a combined mode of developing both new drugs and innovative drug delivery systems in this century. Hence, for developing countries with relatively limited financial resources, a smart strategic move would be to focus on the development of new DDS, which has a significantly higher benefit/risk ratio when comparing to the development of a new drug. Because of the unmatched reaction efficiency and a repetitive action mode, the therapeutic activity of a single bio-macromolecular drug (e.g., protein toxins, gene products, etc.) is equivalent to about 10 –10 of that from a conventional small molecule anti-cancer agent (e.g., doxorubicin). Hence, bio-macromolecular drugs have been recognized around the world as the future “drug-of-choice”. Yet, among the>10000 drugs that are currently available, only ~150 of them belong to these bio-macromolecular drugs (an exceedingly low 1.2%), reflecting the difficulties of utilizing these agents in clinical practice. In general, the bottleneck limitations of these bio-macromolecular drugs are two-fold: (1) the absence of a preferential action of the drug on tumor cells as opposed to normal tissues, and (2) the lack of ability to cross the tumor cell membrane. In this review, we provide strategies of how to solve these problems simultaneously and collectively via the development of innovative drug delivery systems. Since worldwide progress on bio-macromolecular therapeutics still remains in the infant stage and thus open for an equal-ground competition, we wish that this review would echo the desire to industrialized countries such as China to set up its strategic plan on developing delivery systems for these bio-macromolecular drugs, thereby realizing their clinical potential.

Keywords： delivery systems     bio-macromolecular drugs     cell penetrating peptides    

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The Bioprospecting of Microbial-Derived Antimicrobial Peptides for Sustainable Agriculture Review

Shuhua Lin, Xuan Chen, Huimin Chen, Xixi Cai, Xu Chen, Shaoyun Wang

Engineering 2023, Volume 27, Issue 8,   Pages 222-233 doi: 10.1016/j.eng.2022.08.011

Abstract: Among such strategies, antimicrobial peptides (AMPs) with broad-spectrum antimicrobial activity and multifaceted

Keywords： Antibiotic alternatives     Microbial-derived AMPs     Sustainable agricultural systems    

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Rational Design of and Mechanism Insight into an Efficient Antifreeze Peptide for Cryopreservation

Haishan Qi,Yihang Gao,Lin Zhang,Zhongxin Cui,Xiaojie Sui,Jianfan Ma,Jing Yang,Zhiquan Shu,Lei Zhang,

Engineering doi: 10.1016/j.eng.2023.01.015

Abstract: The development of effective antifreeze peptides to control ice growth has attracted a significant amountIn this way, several peptides with notable antifreeze activity were developed.

Keywords： Antifreeze peptides     Evolution analysis     Ice recrystallization inhibition     Molecular dynamics simulation    

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Tethering of Gly-Arg-Gly-Asp-Ser-Pro-Lys Peptides on Mg-Doped Hydroxyapatite

Alessandro Pistone, Daniela Iannazzo, Claudia Espro, Signorino Galvagno, Anna Tampieri, Monica Montesi, Silvia Panseri, Monica Sandri

Engineering 2017, Volume 3, Issue 1,   Pages 55-59 doi: 10.1016/J.ENG.2017.01.007

Abstract:

Stem cell homing, namely the recruitment of mesenchymal stem cells (MSCs) to injured tissues, is highly effective for bone regeneration in vivo. In order to explore whether the incorporation of mimetic peptide sequences on magnesium-doped (Mg-doped) hydroxyapatite (HA) may regulate the homing of MSCs, and thus induce cell migration to a specific site, we covalently functionalized MgHA disks with two chemotactic/haptotactic factors: either the fibronectin fragment III1-C human (FF III1-C), or the peptide sequence Gly-Arg-Gly-Asp-Ser-Pro-Lys, a fibronectin analog that is able to bind to integrin transmembrane receptors. Preliminary biological evaluation of MSC viability, analyzed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test, suggested that stem cells migrate to the MgHA disks in response to the grafted haptotaxis stimuli.

Keywords： Mg-doped hydroxyapatite     Mesenchymal stem cells     Chemotactic/haptotactic factors     Bone tissue engineering    

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Title Author Date Type Operation

Cationic and amphipathic cell-penetrating peptides (CPPs): Their structures and

Jennica L. Zaro,Wei-Chiang Shen

Journal Article

Enzyme-instructed self-assembly of peptides containing phosphoserine to form supramolecular hydrogels

Jie Zhou, Xuewen Du, Jiaqing Wang, Natsuko Yamagata, Bing Xu

Journal Article

Significance and strategies in developing delivery systems for bio-macromolecular drugs

Huining HE, Qiuling LIANG, Meong Cheol SHIN, Kyuri LEE, Junbo GONG, Junxiao YE, Quan LIU, Jingkang WANG, Victor YANG

Journal Article

The Bioprospecting of Microbial-Derived Antimicrobial Peptides for Sustainable Agriculture

Shuhua Lin, Xuan Chen, Huimin Chen, Xixi Cai, Xu Chen, Shaoyun Wang

Journal Article

Rational Design of and Mechanism Insight into an Efficient Antifreeze Peptide for Cryopreservation

Haishan Qi,Yihang Gao,Lin Zhang,Zhongxin Cui,Xiaojie Sui,Jianfan Ma,Jing Yang,Zhiquan Shu,Lei Zhang,

Journal Article

Tethering of Gly-Arg-Gly-Asp-Ser-Pro-Lys Peptides on Mg-Doped Hydroxyapatite

Alessandro Pistone, Daniela Iannazzo, Claudia Espro, Signorino Galvagno, Anna Tampieri, Monica Montesi, Silvia Panseri, Monica Sandri

Journal Article